Volodymyr Sirenko has established reputation and is compared by the international press to brilliant conductors such as Esa-Pekka Salonen and Simon Rattle. He was born in the Poltava region in Ukraine. In 1989 he graduated from Kyiv Conservatoire where he studied conducting under Allin Vlasenko and a year later became finalist at the International Conducting Competition in Prague. Sirenko was appointed to the position of the Chief Conductor of the Ukrainian Radio Symphony Orchestra in 1991, which he held until 1999 when he became Artistic Director and Chief Conductor of the celebrated National Symphony Orchestra of Ukraine (former Kiev State Symphony Orchestra).

Volodymyr Sirenko is an Honored Figure of Arts of Ukraine (1997) and of the Russian Federation (2003). In 2001 he received Ukraine's most prestigious award - the National Shevchenko Prize.

Sirenko has frequently toured Russia, USA, South Korea, France, Italy, Germany, Spain, the Netherlands, Poland, Slovakia, Bulgaria, Belgium, the UK amongst other countries. He has worked with many orchestras abroad including the Moscow Philharmonic, the St Petersburg Philharmonic, the Sinfonia Warsovia, the Russian State Symphony Orchestra, the Bratislava Radio Symphony. He has appeared at numerous concert halls around the world including the Great Hall of Moscow Conservatoire, the Great Hall of St Petersburg Conservatoire, the Théâtre des Champs-Elisés and the Opéra Comique in Paris, the Concertgebouw (Amsterdam), the Centre Manuel de Falla, the Filharmonia Narodowa (Warsaw).

Volodymyr Sirenko conducted the Royal Philharmonic Orchestra in the finals of the Benjamin Britten International Violin Competition in 2004.